An Ectoin containing inhalation solution has already shown first positive proof of concept results after application with patients suffering from mild asthma or pollutant induced lung inflammation. Also ahabituation effecthas not been observed. Sinupret forte and Medical Device, Drug-like in Sinusitis - Clinical ... Thank you for your interest in spreading the word on European Respiratory Society . Epub 2022 Jan 17. Vielen Dank für diesen Bericht. The https:// ensures that you are connecting to the The corrected database underwent a plausibility test for the range of single variables. A multi-centre, prospective, open-label, post-market follow-up study according to Article 61 and Part-B Annex XIV Medical Device Regulation (MDR 2017/745) and conforming to International Organization for Standardization - Clinical investigation of medical devices for human subjects - Good clinical practice (ISO 14155:2020) requirements. The expiry date is given on the product itself and on the outer packaging. G. Lentzen and T. Schwarz, “Extremolytes: natural compounds from extremophiles for versatile applications,” Applied Microbiology and Biotechnology, vol. The 100% natural single molecule provides excellent anti-aging and cell-protection benefits. 08, pp. Visit 1: (D1): Screening, enrollment and training. Record Verification: October 2010 Sie tun dies, indem sie Besucher über Websites hinweg verfolgen. Pflegeprodukt für Pferde: bi-medEctoin® easy breathe (Ectoin equi) kann die Atemwege und Nüstern von Pferden, Ponies und Eseln schützen, pflegen und reinigen. 1413–1422, 2010. Evolution of the mean number of days with rescue medication follow-up. Acute bronchitis and acute respiratory infections are among the most common diseases for which patients seek medical advice. 2021 Feb 9;2021:8885032. doi: 10.1155/2021/8885032. Ectoin, discovered in 1985, falls into this category. Ectoine has versatile applications in medicine: it is used in cream for dermatitis and antiaging [10, 11], in nasal spray for acute rhinosinusitis [12], and in nasal spray and eye drops for allergic rhinitis [13]. Sputum samples were analyzed using the Human XL Cytokine Array (R&D Systems, Minneapolis, MN, USA). Insbesondere bei Pferden, die unter chronischen Atemwegserkrankungen wie Equinem Asthma leiden, kann die, Select a purchase option to pre order this product, Management von Pferden mit Equinem Asthma. Extended analyses considering period effects revealed that the percentage of neutrophils in sputum was significantly lower after ectoine inhalation than in the placebo group (P=0.035) even after the washout phase. 7286–7296, 2008. • First inhalation solution with natural ectoin • Isoton, sterile and without preservatives The isotone salt solution with ectoin and sea salt protects and moistens the airways naturally. 437–445, 2005. Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial. inhalation solutions) in Europe. Statistical significance could not be demonstrated. Ectoin®, Ectoin® inhalation solution, RonaCare® Ectoin Cost: $679 USD. Currently, nasal sprays, eye drops, mouth and throat sprays, inhalation solutions, and creams are available that can be used to treat symptoms of e.g. Deshalb findet sich das Stressschutz . Patients rated their general health in patient diaries and FU questionnaires on a scale from 0% (very poor) to 100% (very good). Long-term air pollution exposure and living close to busy roads are associated with COPD in women. Preliminary ex vivo and in vivo studies demonstrated that the compatible solute ectoine restores natural apoptosis rates of lung neutrophils and contributes to the resolution of lung inflammation. Ectoine seems to be inferior to Pelargonium sidoides, the combination of thyme herb and primrose root, and the combination of thyme herb with ivy leaves for the treatment of bronchitis. Due to this protective coating, the treated areas are protected from irritations due to allergens or other particles and can sooth and calm. HHS Vulnerability Disclosure, Help The level of statistical significance was set to 5% for all tests. A multi-talent for skin and mucous membranes. Die 1. an den Nüstern). Ectoin surrounds treated areas with a stable water shell (hydrofilm) on. Change of fractional exhaled nitric oxide for a sub-group of patients performed on-site over study visit at selected study sites follow-up. Symptoms of patients treated with ectoine improved earlier than those of patients treated with saline. P. Kardos, S. Lehrl, W. Kamin, and H. Matthys, “Assessment of the effect of pharmacotherapy in common cold/acute bronchitis – the Bronchitis Severity Scale (BSS),” Pneumologie, vol. Wenn du dich für eine Auswahl entscheidest, wird die Seite komplett aktualisiert. Air one von Hippomed/Neu-Tec Unkomplizierte Handhabung, leicht zu reinigen. BSS: Bronchitis Severity Score; SEM: standard error of the mean. 2014;68(08):542–546. Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study. UK Bank Holidays and Public Holidays 2023/2024 - Sykes Holiday Cottages The other study showed that the mean BSS decreased by 7.2 ± 3.1 in the active treatment group and by 4.9 ± 2.7 in the placebo group [17, 18]. (Supplementary Materials). Ectoin® Containing Inhalation Solution (EIL07) (Class-IIa MDD legacy medical device). App für Praxisbedarf. Präventive Inhalation beim Pferd: Chancen und Risiken Due to this property, symptoms of atopic dermatitis (eczema), allergies, dry nose or dry eyes syndrome and also cough and cold are reduced sustainable. The current study is the first human trial in which the effects of inhaled ectoine on neutrophilic lung inflammation were investigated. Thus, the reduction in the mean BSS of 5.13 ± 3.11 in the ectoine group in our study is greater than the reductions reported for the abovementioned placebo groups. The inhalation solution can be administered with jet, mesh, and ultrasound nebulizers. ectoin pferd hippomed - tigergardenhotel.com This is an open access article distributed under the. NCI CPTC Antibody Characterization Program, Karrasch S, Holz O, Jorres RA. Because this study did not include a placebo control, we compared the BSS reductions observed in this study with those from previous studies. ADD TO CART. If epithelia are stabilized, allergens, particulate matter, and other small particles have more difficulties to penetrate the epithelia and to stress the body. Based on the positive results of a trial with asthmatic patients a study was set up to evaluate Ectoine Inhalation Solution (EIL) in . The ectoine inhalation solution (Ectoin® inhalation solution, bitop AG, Dortmund, Germany) used in this study is a registered medical device indicated for the treatment of airway inflammations. Ectoin is a natural compound produced by bacteria which are able to survive under extreme conditions. Patients and physicians rated the effectiveness of ectoine slightly more favorably than that of saline inhalation solution. 623–634, 2006. Doch die präventive Inhalation steht auch immer wieder in der Kritik. bi-medEctoin® easy breathe ist eine sterile Lösung einzig bestehend aus 13% bi-medEctoin® und Wasser. Objective: The objective of the study was to test whether the daily inhalation of the registered ectoine-containing medical device (Ectoin ® inhalation solution) leads to a reduction of neutrophilic cells and interleukin-8 (IL-8) levels in the sputum of persons with mild symptoms of airway disease due to lifelong exposure to environmental air . The first significant increase in the general health scores was reported beginning on day 2 in both groups. 80, no. In analogy to the physicians’ assessments, the patients’ assessments also showed that general health improved in both groups. Neuste Technik. The ectoine inhalation solution (Ectoin® inhalation solution, bitop AG, Dortmund, Germany) used in this study contained ectoine (1.3%) and sea salt in water. The clinical investigation comprises 4 visits and 1 telephone call. Dermatol Ther (Heidelb). Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, Krutmann J. Int J Chron Obstruct Pulmon Dis. Pferd: Dämpfigkeit, COB, Husten wirksam behandeln mit Medikamenten Inhalation. 29, no. Other sputum and breath condensate biomarkers were analysed. Ectoine-Containing Inhalation Solution versus Saline Inhalation ... Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine. allergies, cough and cold, eczema, or dry skin. Bitop AG Announces Start of Clinical Trial with Ectoin Inhalation ... In the saline group, one patient had a burning sensation in the throat 20 minutes after inhalation. Ectoine - OEL Fastrac with ADE - Affygility Solutions Ectoin® natural is a powerful, multifunctional active ingredient with outstanding, clinically proven efficacy. Why ectoin may be the new niacinamide | Glamour UK The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 26, no. Kleine Dosis, große Wirkung. The patients’ assessments also indicate that symptoms improved more in the ectoine group than in the saline group. Safety and efficacy of ectoine inhalation solution in patients with inflammation and airway obstruction: The EFECT study, Direct activation of sensory afferents by diesel exhaust particles can trigger respiratory symptoms, Maintenance of IRF1 by MAPK inhibition: A mechanism by which DUSP1 reduces glucocorticoid inhibition of CXCL10, Roflumilast but not dexamethasone or fluticasone reduces neutrophilic airway inflammation and hyperreactivity in a murine influenza-induced asthma exacerbation model. Diese Frage kann man nicht so leicht beantworten, denn es kommt darauf an mit welcher Lösung inhaliert wird. sharing sensitive information, make sure you’re on a federal The Wilcoxon signed-ranks test was used to detect significant differences between baseline and final symptom scores. Almost all patients and physicians assessed the tolerability of both treatments as “good” or “very good”. for the therapy of particle induced COPD and asthma. Ectoin für Pferde - Horse Support The products do not contain potentially harmful ingredients such as preservatives or dyes. 20, no. Am J Respir Crit Care Med. helps to decrease skin-aging caused by particulate matter. The differences in the area under the curve for the symptoms of dyspnea and auscultation findings were significant in favor of ectoine (P < 0.05). Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Change in weekly mean evening Peak Expiratory Flow (ePEF). Leichte Handhabung und Reinigung. Any use of oral/parenteral corticosteroid within 8 weeks of Visit 1. Change in weekly mean morning peak expiratory flow (PEF). The Ectoin® Inhalation Solution has been developed by bitop to reduce inflammations of the airways in case of pulmonary diseases such as bronchitis, asthma, or chronic obstructive pulmonary disease (COPD). Almost all patients and physicians assessed the ectoine inhalation solution (96.1% of patients and 97.4% of physicians) and the saline inhalation solution (96.4% of patients and 96.4% of physicians) as being “good” or “very good”. Here you will find the most frequently asked questions.Please click on the question to find the appropriate answer. We also thank the patients who participated in this study. The results of the EFECT study support the outcome of other studies that the membrane stabilizing Ectoin reduces epithelia derived inflammatory processes. The observational study design allows for investigation of the study medication under routine medical practice; thus, randomization and placebo control are not permitted. However, it is important to note that the herbal drug Pelargonium sidoides may cause hepatotoxicity [22]. In this pilot study, conducted under real-life conditions, ectoine inhalation solution seems to be slightly more effective than saline inhalation solution for the treatment of acute bronchitis and acute respiratory infections. Schon kurz nach den ersten Inhalationen mit LUNG floss es nur so aus ihm heraus. Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals. Experienced an acute asthma exacerbation requiring emergency room treatment within 4 weeks or hospitalisation within 8 weeks of Visit 1. FOIA What proper dosage of Ectoin®-containing products should I take? Kein Wunder also, dass immer mehr Pferdebesitzer ihre Pferde auch präventiv inhalieren möchten. Reductions in symptom scores from V1 to V2 and from V1 to FU. Completion of PAQLQ, ACQ-7and AQLQ+12 questionnaires and FeNO assessment. Purpose. Müller D, Lindemann T, Shah-Hosseini K, Scherner O, Knop M, Bilstein A, Mösges R. Eur Arch Otorhinolaryngol. 211–218, 2007. 57–65, 2014. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Unauthorized use of these marks is strictly prohibited. bitop AG - Witten, Germany - bionity.com Until today there are no data available that the Ectoin® effect decreases if the Ectoin®-containing products are used for an extended period of time. The groups of KU and UK have received research grants from bitop AG. BSS: Bronchitis Severity Score;…, Baseline-adjusted symptom scores (mean ±…, Baseline-adjusted symptom scores (mean ± SEM; analyses of the area under the curve…, MeSH The decision to use ectoine inhalation solution or saline inhalation solution was made by the patients before being included. With stand alone inhalation products and inhalation systems available for clinical trials and marketing partnerships, Activaero's technologies allow for the most precise and efficient patient-tailored pulmonary delivery. The area under the curve of baseline-adjusted symptom scores shown in Figure, Baseline-adjusted symptom scores (mean ± SEM; analyses of the area under the curve are presented in Table, Copyright © 2019 Binh-Hai Tran et al. 20, 2015. Welche Medikamente in welcher Dosis geeignet? Abbreviations: EFECT, An efficacy and feasibility…, Study design of the double-blinded placebo-controlled crossover study. An official website of the United States government. B. Kemmerich, “Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough,” Arzneimittel-Forschung/Drug Research, vol. 2008;74(23):7286–7296. and transmitted securely. Careers. In the cosmetics business both products are marketed worldwide by Merck KGaA (Darmstadt). Minimum 3 days of training following V1 the morning Peak Expiratory Flow (mPEF) is to be measured in the morning upon awakening before taking any asthma controller/rescue medication. 1, article no. A University of Minnesota Twin Cities-led…, New simulations suggest, for the first time, that cocoons of debris around dying stars likely emit gravitational waves Cocoons form as a massive star sheds debris while collapsing into a…, Ectoine: a natural compound reduces lung inflammation, Ecology, The Environment and Conservation. By means of Ectoin ® it reduces the inflammation of the nasal mucosa and the sinuses and reduces the symptoms of common cold.. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Similarly, photo-protective effects could be shown, so that Ectoin®protects the skin from the damaging effects of the sun. It's an amino acid found within and derived from several types of bacteria, but don't be put off by the word "bacteria.". PARI Protect inhalation solution with ecoToin ampoules, 10x2.5 ml bitop AG and Activaero collaborate on clinical study of inhalable ... Another remarkable property of Ectoin is protecting the epidermal immune cells called Langerhans cells from UV damage. pore füllt sich immer wieder mit talg; fehlerfortpflanzung differenz Evolution of the mean number of days with rescue medication. Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface. Applied and Environmental Microbiology. Flexibles Maskenmaterial für mehr Komfort. Was Abstrich Fakultät bank holidays in august uk Hollywood Arithmetik Sumpf Data were entered in the database by two persons independently to avoid errors. The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis. If epithelia are stabilized, allergens, particulate matter, and other small particles have more difficulties to penetrate the epithelia and to stress the body. JK acts as a consultant for bitop AG. No interventions were needed for these events. A placebo control is not allowed in this study design; instead, we compared ectoine inhalation solution with an active control—normal saline inhalation solution. The differences in the area under the curve for the symptoms of dyspnea and auscultation findings were significant in favor of ectoine (P < 0.05). This fact is proven by results of various experiments. Enter multiple addresses on separate lines or separate them with commas. 2009;37(Pt 4):819–823. You will learn from your pharmacist or druggist which products contain Ectoin®. Subsequently, the final screening assessment and training of PEF recording will be performed. Welche Vorteile hat die präventive Inhalation? The substance is known to stabilize cells and protect them against environmental stress. Klaus Unfried reports grants from bitop AG (Dortmund, Germany). In the race to develop fusion energy, each unique approach requires its own…, … could improve performance of quantum computers and artificial intelligence. One patient in each group did not appear at V2. From V1 to V2, the general health score increased by 30.6% in the ectoine group and by 30.6% in the saline group. The natural protection molecule Ectoin® is made in Germany and provides a 100% natural Data of these patients were included in the analysis using the last-value-carried-forward method. In the recent issue of the European Respiratory Journal (Feb 2013; 41:433-442) the scientists describe that application of ectoine has also the ability to ameliorate ongoing lung inflammation. 2009 Jul 1;180(1):29-35. doi: 10.1164/rccm.200812-1911OC. Treatment of Respiratory Tract Infection and/or Acute Bronchitis With Ectoin Inhalation Solution. This study investigated ectoine inhalation solution for the treatment of acute bronchitis and/or acute respiratory infections. Gerade bei Atemwegserkrankungen bei Pferden sollte man diesen Ratschlag beherzigen, denn allzu schnell wird aus einer harmlosen Atemwegsinfektion ein chronisches Leiden. The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis. After treatment, symptom scores decreased significantly in both groups (P < 0.05); the reduction in symptom scores was slightly greater in the ectoine group than in the saline group. Bitop AG Announces Start of Clinical Trial with Ectoin Inhalation Solution in Patients with Inflammation and Obstruction of the Airways | Witten, Germany, November 04, 2010 / b3c newswire / - bitop analgesics, antibiotics, cold remedies, herbals etc.? This prospective, controlled, observational study comprised an inclusion visit (day 1), a final visit (day 7), and a follow-up questionnaire (day 17). The duration of participation in the clinical study will be 42±2 days (6 weeks) from enrollment). This observational study was designed in accordance with the German Medical Devices Act, section 23b, and aimed to investigate the study medications under routine clinical practice. Ectoin® natural repairs improve damaged, aged or stressed, and irritated skin, promoting skin barrier repair and long-term hydration. Contact:Dr. Klaus UnfriedIUF Leibniz Research Institute for Environmental MedicineAuf'm Hennekamp 5040225 Düsseldorf GermanyPhone #49 (0) 211 3389-0Klaus.Unfried@uni-duesseldorf.de, All latest news from the category: Health and Medicine. This fact is proven by results of various experiments. Zhang H, Liang Z, Zhao M, Ma Y, Luo Z, Li S, Xu H. Front Bioeng Biotechnol. Nevertheless, because of varying baseline parameters, direct comparisons of the BSS between studies are informative only to a limited extent. However, the reduction is smaller than that of the placebo group in another study using Pelargonium sidoides [21]. ECTOIN forms a layer of water, the ecoToin hydrocomplex. Completion of Paediatric Asthma Quality of Life Questionnaire (PAQLQ), ACQ-7 and Asthma Quality of Life Questionnaire (AQLQ+12) questionnaires as applicable and Fractional exhaled Nitric Oxide (FeNO) assessment. Read our, ClinicalTrials.gov Identifier: NCT05699941, Interventional Produkttest Hanfpellets, Ectoin Inhalation und ... - YouTube Federal government websites often end in .gov or .mil. Ectoin is produced on a natural way (fermentative) by means of such microorganisms that are protected by Ectoin from environmental stress. The tolerability of the treatment was assessed by investigators and patients independently at V2 as “poor”, “satisfactory”, “good”, or “very good”. Medikamente inhalieren Pferd bei Dämpfigkeit, COB, Husten - Salin MedicAir Compatible solutes are natural substances that are known to stabilize cellular functions. Based on the positive results of a trial with asthmatic patients a study was set up to evaluate Ectoine Inhalation Solution (EIL) in subjects with mild airway obstruction and inflammation. History of Changes for Study: NCT01225965 - ClinicalTrials.gov Participation in any other clinical study within the last 4 weeks prior to screening. Mit der präventiven Inhalation möchte man Atemwegserkrankungen verhindern und nicht auslösen. official website and that any information you provide is encrypted The treatment itself was administered from day 1 to day 7. The end-of-treatment assessment will be the mean of mPEF at end of week 4 along with a repeat of all on-site questionnaires and assessments performed at V2. Mit der Entscheidung "Nur essentielle Cookies akzeptieren" werden wir Ihre Privatsphäre respektieren und keine Cookies setzen, die nicht für den Betrieb der Seite notwendig sind. Targeting the EGFR-ERK axis using the compatible solute ectoine to stabilize CFTR mutant F508del. Flexineb - DE - Der innovative Pferde-Inhalator After the successful feasibility a long term study extension will investigate the effect of Ectoin Inhalation Solution of lung function decline, lung ageing and inflammation. The results of this study suggested that ectoine inhalation solution seems to be slightly more effective than normal saline inhalation solution in the treatment of acute bronchitis and acute respiratory infections.
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